Mar 14

A Post Antibiotic Apocalypse: What Could Happen In A World Without Antibiotics

Imagine The Unimaginable: A World Without Antibiotics

Think for a moment how often we take antibiotics for granted. An annoying throat infection, a minor skin wound that's getting a little red and puffy – often, our first thought is, "maybe I need some antibiotics." These medications have become such a cornerstone of modern healthcare that it's hard to picture life without them. But what if the security of a “cure” was gone? Imagine a world where these miracle drugs no longer worked, where even the simplest infections could once again become potentially fatal. This isn't a far-fetched dystopian fantasy; it's a very real possibility if we fail to act on antibiotic resistance, a challenge largely fueled by the failure of what we call antimicrobial stewardship (AMS).

A Glimpse Into The Past: The Pre-Antibiotic Era

To truly grasp the gravity of this situation, let's take a step back in time, before the discovery of penicillin in 1928. In this pre-antibiotic era, the medical landscape was drastically different. Simple cuts and scrapes could become serious infections, sometimes requiring drastic measures like the amputation of a limb. Essentially, the physical removal of the infection. Childbirth was a much riskier event for both mother and child, and even common illnesses like scarlet fever could lead to severe complications, with a risk to the sufferer’s survival. Surgery was fraught with danger, with deadly systemic (bloodstream infections) like bacteremia or septicemia being a frequent occurrence. Tuberculosis (TB) serves as a stark reminder of this era. The primary treatment available was "fresh air and bed rest" in sanatoriums, relying solely on the body's immune system, with a grim chance of a full recovery. The arrival of streptomycin, the first antibiotic for TB, completely revolutionised treatment, akin to the impact of modern expensive cancer drugs or hepatitis C cures. This historical perspective highlights that antibiotics aren't just convenient; they are fundamentally lifesaving.

The Silent Threat: Understanding Antibiotic Resistance

So, how do we get to a point where these life-saving drugs might stop working? The culprit is antibiotic resistance. Bacteria, like all living organisms, can evolve. When exposed to antibiotics, the bacteria that have the genetic mutations allowing them to survive will reproduce, passing on their resistance to other bacteria, not necessarily the same species as themselves. This is truly natural selection in action. Our overuse and misuse of antibiotics can dramatically accelerate this process. Think about it: every time an antibiotic is used, it creates an environment where only the resistant bacteria can survive the antibacterial onslaught.  Bacteria are incredibly adaptable; they can even share their genes for resistance with other bacteria, sometimes even different species, allowing resistance to spread rapidly. This means that resistance developed in one type of bacteria could potentially render antibiotics ineffective against others.

The Dire Consequences: Life In A Post-Antibiotic World

Imagine returning to a time where a minor infection could have devastating consequences. Surgeries, even routine ones, would become incredibly risky due to the high chance of an untreatable post-operative infection. Procedures like organ transplants and chemotherapy, often relying on antibiotics to protect vulnerable patients from infection post-surgery or during treatment, could become too dangerous to consider. Childbirth would again carry a significant risk of infection for mothers and newborns. We could see a resurgence of diseases that were once well-controlled, like tuberculosis, with treatment options severely limited. Some experts predict that if we fail to get antibiotic resistance under control, we could face a future where 10 million more people a year could die by 2050 from infections that are currently treatable. Some hospitals are already having to make the difficult decision as whether to offer certain treatments, like cancer therapy, due to the high risk of untreatable infections. This isn't just a medical concern; it's a societal one that could have a profound economic impact.


The Failure Of Stewardship: Why We Face This Risk

This looming crisis is largely a consequence of failures in antimicrobial stewardship (AMS) – the effort to use antibiotics wisely and appropriately. Several factors contribute to this failure. In healthcare settings, antibiotics can be used incorrectly; for longer than necessary after surgery, or the wrong type of antibiotic is prescribed, a “kill all” approach. Incorrect diagnoses can lead to broad-spectrum antibiotics being used when a more targeted approach might be the better choice for the infection presenting. There can also be a degree of "therapeutic inertia," where antibiotic treatments are continued simply because the patient is improving, without reassessing if a more appropriate option exists.

Outside of hospitals, the issue is compounded by patients expecting "a pill for every ill", sometimes leading to doctors prescribing antibiotics even for viral infections where they are ineffective. (Remember the days when your GP had his prescription pad already filled out with a broad-spectrum antibiotic for you to collect?). Patients may also not complete their prescribed course of antibiotics once they start feeling better, which is a major problem because it allows some bacteria to survive and potentially develop resistance. Furthermore, the use of antibiotics in agriculture to promote growth in livestock has been a significant contributor to the rise of antibiotic-resistant organisms that can then spread to humans. The perception of antibiotics as cheap and readily available "throwaway items" also fosters a cavalier attitude towards their use.  

Taking Action 

  • Preserving the Power of Antibiotics: The good news is that it's not too late to make a difference. Effective antimicrobial stewardship is crucial, and it requires a multi-pronged approach involving healthcare professionals, patients, and policymakers.
  • For Nurses and Other Healthcare Professionals: We need to champion the appropriate use of antibiotics in aged care as well as other healthcare institutions, adhering to guidelines and questioning unnecessary prescriptions. Educating patients on the importance of completing their full course of antibiotics, even if they feel better, is vital. We must also advocate for and participate in antimicrobial stewardship programs within our facilities and health institutions. Staying informed about local resistance patterns and promoting infection prevention measures like hand hygiene are the key.
  • For Patients and the Public: Understanding that many common infections, especially viral ones, do not require antibiotics, is the first step. We need to trust our healthcare providers' advice and not pressure them for antibiotics where they are not indicated. If antibiotics are prescribed, it's crucial to take the full course as directed, even if you start feeling better. Practicing good hygiene, such as frequent handwashing, can help prevent infections from spreading in the first place.
  • For Policymakers and the Pharmaceutical Industry: Strengthening surveillance and monitoring of antibiotic resistance is essential to inform public health policies. We need to incentivise and support research and development for new antibiotics and alternative therapies to combat resistance. Exploring strategies like reserving new antibiotics as a "drug of last resort" can help preserve their effectiveness. Addressing the use of antibiotics in agriculture, particularly for growth promotion, through regulation and alternative practices is also crucial.

Our Collective Responsibility: Securing The Future Of Antibiotics

The threat of a world without effective antibiotics is a slow-moving pandemic, but it's one we can still avert. It requires a fundamental shift in how we view and use these precious drugs. Just as environmental stewardship is vital for our planet, antimicrobial stewardship is essential for the future of healthcare. It’s not just about individual choices; it’s about a collective responsibility to protect a medical discovery that has saved countless lives since 1928.

Conclusion: Preserving Our Future

In conclusion, we've journeyed through a time before antibiotics, explored the alarming rise of resistance, and glimpsed the perilous future we face if these miracle drugs fail in the fight to treat infections. The inappropriate and overuse of antibiotics in both humans and animals is accelerating this crisis, threatening to return us to an era where simple infections could once again become deadly. However, by embracing antimicrobial stewardship at all levels – from individual choices to policy changes – we can still preserve the power of antibiotics for future generations. What steps will you take today to ensure these life-saving medicines remain effective?

To continue this vital conversation and delve deeper into the strategies we can adopt, explore our related posts on antibiotic stewardship or consider sharing your thoughts.

If you are interested in how bacteria develop resistance, with diagrams, see our previous blog post on “Antibiotic Resistance, A Cellular Level Perspective”  “Antibiotic Resistance, A Cellular Level Perspective”